ITT2813
ITT2813
- Catalog: ITT2813
- Gene/Protein: MSN
- Product Description: Immunotag™ Moesin/Ezrin/Radixin Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | Moesin/Ezrin/Radixin |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Moesin/Ezrin/Radixin, at AA range: 500-580 |
| Specificity | Moesin/Ezrin/Radixin Polyclonal Antibody detects endogenous levels of Moesin/Ezrin/Radixin protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | MSN |
| Accession No. | P26038/P35241/P15311 O35763/P31977 |
| Alternate Names | MSN; Moesin; Membrane-organizing extension spike protein; RDX; Radixin; EZR; VIL2; Ezrin; Cytovillin; Villin-2; p81 |
| Description | moesin(MSN) Homo sapiens Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Leukocyte transendothelial migration,Regulates Actin and Cytoskeleton, |
| Protein Expression | Epithelium,Pancreas,Placenta,Platelet,Skin, |
| Subcellular Localization | uropod,extracellular space,nucleus,cytoplasm,cytoskeleton,plasma membrane,microvillus,focal adhesion,basolateral plasma membrane,apical plasma membrane,extrinsic component of membrane,filopodium,pseudopodium,microvillus me |
| Protein Function | function:Probably involved in connections of major cytoskeletal structures to the plasma membrane.,PTM:Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures.,similarity:Contains 1 FERM domain.,subcellular location:Phosphorylated form is enriched in microvilli-like structures at apical membrane.,subunit:In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity). Binds SLC9A3R1.,tissue specificity:In all tissues and cultured cells studied., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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