ITT2908
ITT2908
- Catalog: ITT2908
- Gene/Protein: MTERF
- Product Description: Immunotag™ mTERF Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | mTERF |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MTERF. AA range:267-316 |
| Specificity | mTERF Polyclonal Antibody detects endogenous levels of mTERF protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | MTERF |
| Accession No. | Q99551 Q8CHZ9 |
| Alternate Names | MTERF; Transcription termination factor; mitochondrial; Mitochondrial transcription termination factor 1; mTERF |
| Description | mitochondrial transcription termination factor 1(MTERF1) Homo sapiens This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Colon,Placenta,Uterus, |
| Subcellular Localization | mitochondrion,mitochondrial matrix,mitochondrial nucleoid, |
| Protein Function | domain:Composed of three leucine zippers, one of which is bipartite, and two widely spaced basic domains. There is evidence that the leucine zippers form and intramolecular three-stranded coiled-coil that brings the basic domains together to form a DNA-binding motif.,function:Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene, this region comprises a tridecamer sequence critical for directing accurate termination. Probably requires one or more components for termination activity.,PTM:Phosphoprotein with mostly four phosphate groups. While the DNA-binding activity is unaffected by the phosphorylation state, only the phosphorylated form of the protein is active for termination activity. Functioning seems to be regulated by phosphorylation.,similarity:Belongs to the mTERF family.,subunit:Monomer., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|