ITT2916
ITT2916
- Catalog: ITT2916
- Gene/Protein: TFAM
- Product Description: Immunotag™ mtTFA Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | mtTFA |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TFAM. AA range:131-180 |
| Specificity | mtTFA Polyclonal Antibody detects endogenous levels of mtTFA protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | TFAM |
| Accession No. | Q00059 P40630 |
| Alternate Names | TFAM; TCF6; TCF6L2; Transcription factor A; mitochondrial; mtTFA; Mitochondrial transcription factor 1; MtTF1; Transcription factor 6; TCF-6; Transcription factor 6-like 2 |
| Description | transcription factor A, mitochondrial(TFAM) Homo sapiens This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012], |
| Cell Pathway/ Category | Stem cell pathway, Protein_Acetylation |
| Protein Expression | Lymphocyte,Pooled,Uterus, |
| Subcellular Localization | nucleus,mitochondrion,mitochondrial matrix,cytosol,mitochondrial nucleoid, |
| Protein Function | function:Involved in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA.,similarity:Contains 2 HMG box DNA-binding domains.,subunit:Interacts with TFB1M and TFB2M., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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