ITT2949
ITT2949
- Catalog: ITT2949
- Gene/Protein: MYO9B
- Product Description: Immunotag™ Myosin IXb Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Myosin IXb |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Myosin IXb, at AA range: 280-360 |
| Specificity | Myosin IXb Polyclonal Antibody detects endogenous levels of Myosin IXb protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | MYO9B |
| Accession No. | Q13459 Q9QY06 Q63358 |
| Alternate Names | MYO9B; MYR5; Unconventional myosin-IXb; Unconventional myosin-9b |
| Description | myosin IXB(MYO9B) Homo sapiens This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011], |
| Protein Expression | Epithelium,Liver,Placenta,Platelet,Small intestine,Uterus, |
| Subcellular Localization | intracellular,cytoplasm,cytosol,actin filament,cell cortex,actin cytoskeleton,membrane,myosin complex,perinuclear region of cytoplasm, |
| Protein Function | disease:Genetic variation in MYO9B is the cause of susceptibility to celiac disease 4 (CELIAC4) [MIM:609753]. Celiac disease [MIM:212750] is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive.,function:Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho.,online information:MYO9B entry,sequence caution:Chimera. The C-terminal sequence from position 1917 onwards is probably a chimera.,similarity:Contains 1 myosin head-like domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 4 IQ domains.,subcellular location:In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region.,tissue specificity:Expressed predominantly in peripheral blood leukocytes and at lower levels, in thymus, spleen, testis, prostate, ovary, brain, small intestine and lung., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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