ITT2975
ITT2975
- Catalog: ITT2975
- Gene/Protein: NAB2
- Product Description: Immunotag™ NAB2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | NAB2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NAB2. AA range:261-310 |
| Specificity | NAB2 Polyclonal Antibody detects endogenous levels of NAB2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | NAB2 |
| Accession No. | Q15742 Q61127 |
| Alternate Names | NAB2; MADER; NGFI-A-binding protein 2; EGR-1-binding protein 2; Melanoma-associated delayed early response protein; Protein MADER |
| Description | NGFI-A binding protein 2(NAB2) Homo sapiens This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008], |
| Protein Expression | Epithelium,Placenta,Skin, |
| Subcellular Localization | nucleus, |
| Protein Function | domain:The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.,domain:The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.,function:Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.,induction:By serum and PMA stimulation.,similarity:Belongs to the NAB family.,subcellular location:Isoform 2 is not localized to the nucleus.,subunit:Homomultimers may associate with EGR1 bound to DNA.,tissue specificity:Widely expressed at low levels. Highly expressed in melanoma cell lines., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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