ITT2991
ITT2991
- Catalog: ITT2991
- Gene/Protein: NCK2
- Product Description: Immunotag™ Nck-2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Nck-2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NCK2. AA range:331-380 |
| Specificity | Nck-2 Polyclonal Antibody detects endogenous levels of Nck-2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | NCK2 |
| Accession No. | O43639 O55033 |
| Alternate Names | NCK2; GRB4; Cytoplasmic protein NCK2; Growth factor receptor-bound protein 4; NCK adaptor protein 2; Nck-2; SH2/SH3 adaptor protein NCK-beta |
| Description | NCK adaptor protein 2(NCK2) Homo sapiens This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | ErbB_HER,Axon guidance,T_Cell_Receptor,Pathogenic Escherichia coli infection, |
| Protein Expression | Lung,Placenta,Platelet,Uterus, |
| Subcellular Localization | cytoplasm,endoplasmic reticulum,trans-Golgi network,cytosol,vesicle membrane,synapse, |
| Protein Function | function:Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH3 domains.,similarity:Contains 3 SH3 domains.,subunit:Interacts with DOCK1, PINCH and TGFB1I1. Part of a complex containing PPP1R15B, PP1 and NCK2.,tissue specificity:Ubiquitous., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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