ITT3176
ITT3176
- Catalog: ITT3176
- Gene/Protein: NOX5
- Product Description: Immunotag™ Nox5 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Nox5 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NOX5. AA range:677-726 |
| Specificity | Nox5 Polyclonal Antibody detects endogenous levels of Nox5 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | NOX5 |
| Accession No. | Q96PH1 |
| Alternate Names | NOX5; NADPH oxidase 5 |
| Description | NADPH oxidase 5(NOX5) Homo sapiens This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011], |
| Protein Expression | Kidney epithelium,PCR rescued clones,Spleen,Testis, |
| Subcellular Localization | endoplasmic reticulum,endoplasmic reticulum membrane,integral component of membrane, |
| Protein Function | cofactor:FAD.,cofactor:Magnesium.,developmental stage:Expressed in fetal tissues.,enzyme regulation:Activated by calcium which induces conformational changes and interaction between the N-terminal regulatory region and the C-terminal catalytic region. Inhibited by diphenylene iodonium.,function:Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis.,induction:Down-regulated by TGFB1.,miscellaneous:Isoforms 3 and 4 of this protein have four functional calcium-binding sites. Isoforms 1 and 2 have the third EF-hand domain interrupted by an insert.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 ferric oxidoreductase domain.,similarity:Contains 4 EF-hand domains.,tissue specificity:Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen and lymph nodes. Isoform 3 is expressed in spleen. Isoform 4 is expressed in testis. Also detected in ovary, placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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