ITT3223
ITT3223
- Catalog: ITT3223
- Gene/Protein: LEP
- Product Description: Immunotag™ Ob Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Ob |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the N-terminal region of human Ob |
| Specificity | Ob Polyclonal Antibody detects endogenous levels of Ob protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | LEP |
| Accession No. | P41159 P41160 P50596 |
| Alternate Names | LEP; OB; OBS; Leptin; Obese protein; Obesity factor |
| Description | leptin(LEP) Homo sapiens This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Cytokine-cytokine receptor interaction,Neuroactive ligand-receptor interaction,Jak_STAT,Adipocytokine, |
| Protein Expression | PCR rescued clones,Placenta, |
| Subcellular Localization | extracellular region,extracellular space,cytoplasm, |
| Protein Function | disease:Defects in LEP may be a cause of autosomal recessive obesity [MIM:601665].,function:May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.,online information:Leptin entry,similarity:Belongs to the leptin family.,subunit:Interacts with SIGLEC6., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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