ITT3237
ITT3237
- Catalog: ITT3237
- Gene/Protein: POFUT1
- Product Description: Immunotag™ O-FucT-1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | O-FucT-1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from O-FucT-1, at AA range: 300-380 |
| Specificity | O-FucT-1 Polyclonal Antibody detects endogenous levels of O-FucT-1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | POFUT1 |
| Accession No. | Q9H488 Q91ZW2 Q6EV70 |
| Alternate Names | POFUT1; FUT12; KIAA0180; GDP-fucose protein O-fucosyltransferase 1; Peptide-O-fucosyltransferase 1; O-FucT-1 |
| Description | protein O-fucosyltransferase 1(POFUT1) Homo sapiens This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008], |
| Protein Expression | Bone marrow,Brain,Heart,Liver, |
| Subcellular Localization | endoplasmic reticulum,membrane, |
| Protein Function | catalytic activity:Transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor.,cofactor:Manganese.,function:Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in EGF domains. Plays a crucial role in Notch signaling.,online information:GlycoGene database,online information:Peptide-O-fucosyltransferase 1,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 68 family.,tissue specificity:Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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