ITT3562
ITT3562
- Catalog: ITT3562
- Gene/Protein: SESN1
- Product Description: Immunotag™ PA26 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PA26 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SESN1. AA range:271-320 |
| Specificity | PA26 Polyclonal Antibody detects endogenous levels of PA26 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SESN1 |
| Accession No. | Q9Y6P5 P58006 |
| Alternate Names | SESN1; PA26; SEST1; Sestrin-1; p53-regulated protein PA26 |
| Description | sestrin 1(SESN1) Homo sapiens This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010], |
| Cell Pathway/ Category | p53, |
| Protein Expression | Lung,Placenta, |
| Subcellular Localization | nucleus,cytoplasm,cytosol,GATOR2 complex, |
| Protein Function | disease:Defects in SESN1 may be involved in heterotaxia. Heterotaxia is an aetiologically heterogeneous condition caused by an abnormal left-right axis formation, resulting in reversed left-right polarity of one or more organ systems.,function:Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth.,induction:Isoforms T2 and isoform T3 are induced by genotoxic stress (UV, gamma-irradiation and cytotoxic drugs) in a p53-dependent manner. Isoform T1 is not induced by p53.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the sestrin family.,tissue specificity:Widely expressed., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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