ITT3586
ITT3586
- Catalog: ITT3586
- Gene/Protein: F2RL2
- Product Description: Immunotag™ PAR-3 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PAR-3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IF,ELISA |
| Recommended Dilution | Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human F2RL2. AA range:38-87 |
| Specificity | PAR-3 Polyclonal Antibody detects endogenous levels of PAR-3 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | F2RL2 |
| Accession No. | O00254 O08675 |
| Alternate Names | F2RL2; PAR3; Proteinase-activated receptor 3; PAR-3; Coagulation factor II receptor-like 2; Thrombin receptor-like 2 |
| Description | coagulation factor II thrombin receptor like 2(F2RL2) Homo sapiens This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012], |
| Cell Pathway/ Category | Neuroactive ligand-receptor interaction, |
| Protein Expression | G-protein coupled receptors,Human retina, |
| Subcellular Localization | extracellular region,plasma membrane,integral component of plasma membrane,integral component of membrane,apical plasma membrane, |
| Protein Function | function:Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with INSC/inscuteable and probably GPSM2.,tissue specificity:Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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