ITT3619
ITT3619
- Catalog: ITT3619
- Gene/Protein: PLD1
- Product Description: Immunotag™ PC-PLD1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PC-PLD1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from PC-PLD1, at AA range: 90-170 |
| Specificity | PC-PLD1 Polyclonal Antibody detects endogenous levels of PC-PLD1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PLD1 |
| Accession No. | Q13393 Q9Z280 P70496 |
| Alternate Names | PLD1; Phospholipase D1; PLD 1; hPLD1; Choline phosphatase 1; Phosphatidylcholine-hydrolyzing phospholipase D1 |
| Description | phospholipase D1(PLD1) Homo sapiens This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011], |
| Cell Pathway/ Category | Glycerophospholipid metabolism,Ether lipid metabolism,Endocytosis,Fc gamma R-mediated phagocytosis,GnRH,Pathways in cancer,Pancreatic cancer, |
| Protein Expression | Aorta endothelial cell,Brain,Cervix carcinoma,Chondrocyte,Epithelium,Skeletal muscle,Testis |
| Subcellular Localization | Golgi membrane,lysosomal membrane,endosome,endoplasmic reticulum membrane,Golgi apparatus,membrane,apical plasma membrane,endocytic vesicle,late endosome membrane,perinuclear region of cytoplasm, |
| Protein Function | catalytic activity:A phosphatidylcholine + H(2)O = choline + a phosphatidate.,enzyme regulation:Stimulated by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42. Inhibited by oleate.,function:Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic.,online information:Phospholipase D entry,similarity:Belongs to the phospholipase D family.,similarity:Contains 1 PH domain.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 PLD phosphodiesterase domains.,subunit:Interacts with PIP5K1A.,tissue specificity:Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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