ITT3628
ITT3628
- Catalog: ITT3628
- Gene/Protein: PDE4B/PDE4C/PDE4D
- Product Description: Immunotag™ PDE4B/C/D Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PDE4B/C/D |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from PDE4B/C/D, at AA range: 130-210 |
| Specificity | PDE4B/C/D Polyclonal Antibody detects endogenous levels of PDE4B/C/D protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PDE4B/PDE4C/PDE4D |
| Accession No. | Q07343/Q08493/Q08499 P14646/P14644/P14270 |
| Alternate Names | PDE4B; DPDE4; cAMP-specific 3'; 5'-cyclic phosphodiesterase 4B; DPDE4; PDE32; PDE4C; DPDE1; cAMP-specific 3',5'-cyclic phosphodiesterase 4C; DPDE1; PDE21; PDE4D; DPDE3; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; DPDE3; PDE43 |
| Description | phosphodiesterase 4B(PDE4B) Homo sapiens This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014], |
| Cell Pathway/ Category | Purine metabolism, |
| Protein Expression | Brain,Hippocampus,Retina, |
| Subcellular Localization | gamma-tubulin complex,centrosome,cytosol,voltage-gated calcium channel complex,synaptic vesicle,postsynaptic density,membrane,Z disc,dendritic spine,cell periphery, |
| Protein Function | Additional isoforms seem to exist,catalytic activity:Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.,enzyme regulation:Inhibited by rolipram.,function:May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.,pathway:Purine metabolism; cAMP degradation; AMP from cAMP: step 1/1.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,tissue specificity:Expressed in brain, heart, lung and skeletal muscle., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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