ITT3630
ITT3630
- Catalog: ITT3630
- Gene/Protein: PDGFA
- Product Description: Immunotag™ PDGF-A Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PDGF-A |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the Internal region of human PDGF-A |
| Specificity | PDGF-A Polyclonal Antibody detects endogenous levels of PDGF-A protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PDGFA |
| Accession No. | P04085 P20033 P28576 |
| Alternate Names | PDGFA; PDGF1; Platelet-derived growth factor subunit A; PDGF subunit A; PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide |
| Description | platelet derived growth factor subunit A(PDGFA) Homo sapiens This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015], |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,Cytokine-cytokine receptor interaction,Focal adhesion,Gap junction,Regulates Actin and Cytoskeleton,Pathways in cancer,Glioma,Prostate cancer,Melanoma, |
| Protein Expression | PCR rescued clones, |
| Subcellular Localization | Golgi membrane,extracellular region,extracellular space,endoplasmic reticulum lumen,microvillus,cell surface,membrane,platelet alpha granule lumen, |
| Protein Function | domain:The long form contains a basic insert which acts as a cell retention signal.,function:Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.,miscellaneous:A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor.,similarity:Belongs to the PDGF/VEGF growth factor family.,subunit:Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. Interacts with CSPG4., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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