ITT3658
ITT3658
- Catalog: ITT3658
- Gene/Protein: SERPINF1
- Product Description: Immunotag™ PEDF Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PEDF |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,WB,ELISA |
| Recommended Dilution | WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PEDF. AA range:258-307 |
| Specificity | PEDF Polyclonal Antibody detects endogenous levels of PEDF protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SERPINF1 |
| Accession No. | P36955 P97298 |
| Alternate Names | SERPINF1; PEDF; PIG35; Pigment epithelium-derived factor; PEDF; Cell proliferation-inducing gene 35 protein; EPC-1; Serpin F1 |
| Description | serpin family F member 1(SERPINF1) Homo sapiens This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. [provided by RefSeq, Aug 2016], |
| Protein Expression | Fetal eye,Fetal lung fibroblast,Liver,Muscle,Plasma, |
| Subcellular Localization | extracellular region,basement membrane,extracellular space,extracellular matrix,melanosome,axon hillock,perinuclear region of cytoplasm,extracellular exosome, |
| Protein Function | developmental stage:Expressed in quiescent cells.,domain:The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity.,function:Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.,PTM:The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity.,similarity:Belongs to the serpin family.,subcellular location:Enriched in stage I melanosomes.,tissue specificity:Retinal pigment epithelial cells and blood plasma., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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