ITT3665
ITT3665
- Catalog: ITT3665
- Gene/Protein: PPHLN1
- Product Description: Immunotag™ Periphilin 1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PeriphIL-in 1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PPHLN. AA range:71-120 |
| Specificity | Periphilin 1 Polyclonal Antibody detects endogenous levels of Periphilin 1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PPHLN1 |
| Accession No. | Q8NEY8 Q8K2H1 |
| Alternate Names | PPHLN1; HSPC206; HSPC232; Periphilin-1; Gastric cancer antigen Ga50 |
| Description | periphilin 1(PPHLN1) Homo sapiens The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Colon,Epithelium,Gastric adenocarcinoma,Keratinocyte,Skin,Umbilical cord blood, |
| Subcellular Localization | nucleoplasm,chromosome,cytoplasm,Golgi apparatus,intracellular membrane-bounded organelle, |
| Protein Function | function:Involved in epithelial differentiation and contributes to epidermal integrity and barrier formation.,PTM:Substrate of transglutaminase (in vitro).,subcellular location:In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions.,subunit:Homodimer. Interacts with PPL.,tissue specificity:Ubiquitous., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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