ITT3690
ITT3690
- Catalog: ITT3690
- Gene/Protein: PTGIS
- Product Description: Immunotag™ PGI2 synthase Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PGI2 synthase |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the C-terminal region of human PGI2 synthase |
| Specificity | PGI2 synthase Polyclonal Antibody detects endogenous levels of PGI2 synthase protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PTGIS |
| Accession No. | Q16647 O35074 Q62969 |
| Alternate Names | PTGIS; CYP8; CYP8A1; Prostacyclin synthase; Prostaglandin I2 synthase |
| Description | prostaglandin I2 synthase(PTGIS) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Arachidonic acid metabolism, |
| Protein Expression | Aorta,Brain, |
| Subcellular Localization | extracellular space,nucleus,endoplasmic reticulum,endoplasmic reticulum membrane,caveola,integral component of membrane, |
| Protein Function | catalytic activity:(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate.,cofactor:Heme group.,function:Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).,online information:CYP8A1 alleles,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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