ITT3775
ITT3775
- Catalog: ITT3775
- Gene/Protein: PKIA
- Product Description: Immunotag™ Pki α Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Pki α |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,IF,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Pki α, at AA range: 10-90 |
| Specificity | Pki α Polyclonal Antibody detects endogenous levels of Pki α protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PKIA |
| Accession No. | P61925 P63248 P63249 |
| Alternate Names | PKIA; PRKACN1; cAMP-dependent protein kinase inhibitor alpha; PKI-alpha; cAMP-dependent protein kinase inhibitor; muscle/brain isoform |
| Description | protein kinase (cAMP-dependent, catalytic) inhibitor alpha(PKIA) Homo sapiens The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008], |
| Protein Expression | Skeletal muscle, |
| Subcellular Localization | nucleus,cytoplasm, |
| Protein Function | function:Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.,miscellaneous:The inhibitory site contains regions very similar to the hinge regions (sites that directly interact with the enzyme active site) and "pseudosubstrate site" of the regulatory chains; but, unlike these chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential for inhibition and recognition of the enzyme active site.,similarity:Belongs to the PKI family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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