ITT3785
ITT3785
- Catalog: ITT3785
- Gene/Protein: PKP4
- Product Description: Immunotag™ Plakophilin 4 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PlakophIL-in 4 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PKP4. AA range:185-234 |
| Specificity | Plakophilin 4 Polyclonal Antibody detects endogenous levels of Plakophilin 4 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PKP4 |
| Accession No. | Q99569 Q68FH0 |
| Alternate Names | PKP4; Plakophilin-4; p0071 |
| Description | plakophilin 4(PKP4) Homo sapiens Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015], |
| Protein Expression | Brain,Epithelium,Frontal cortex,Soares breast 2NbHBst,T-cell, |
| Subcellular Localization | spindle pole,cytoplasm,cytoskeleton,plasma membrane,cell-cell junction,cytoplasmic side of plasma membrane,postsynaptic density,cell junction,desmosome,midbody,cell-cell contact zone,perinuclear region of cytoplasm,spindle mi |
| Protein Function | function:May play a role in junctional plaques.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the beta-catenin family.,similarity:Contains 9 ARM repeats.,subcellular location:Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.,subunit:Interacts with PDZD2., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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