ITT3853
ITT3853
- Catalog: ITT3853
- Gene/Protein: MECOM
- Product Description: Immunotag™ PRDM3 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | PRDM3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MECOM. AA range:1-50 |
| Specificity | PRDM3 Polyclonal Antibody detects endogenous levels of PRDM3 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | MECOM |
| Accession No. | Q13465 Q9Z1L8 |
| Alternate Names | MECOM; MDS1; MDS1 and EVI1 complex locus protein MDS1; Myelodysplasia syndrome 1 protein; Myelodysplasia syndrome-associated protein 1 |
| Description | MDS1 and EVI1 complex locus(MECOM) Homo sapiens The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011], |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,Pathways in cancer,Chronic myeloid leukemia, |
| Protein Expression | Kidney,Pancreas, |
| Subcellular Localization | histone deacetylase complex,nucleus,nucleoplasm,cytoplasm,Golgi apparatus,cytosol,aggresome,nuclear speck,intracellular membrane-bounded organelle, |
| Protein Function | disease:A chromosomal aberration involving EVI1 is a cause of chronic myelogenous leukemia (CML). Translocation t(3;21)(q26;q22) with RUNX1/AML1.,disease:A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1.,miscellaneous:Can be produced either as a separate transcript and as a normal fusion transcript with EVI1.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 10 C2H2-type zinc fingers.,subunit:May interact with CTBP1., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|