ITT3863
ITT3863
- Catalog: ITT3863
- Gene/Protein: PCDH11X/PCDH11Y
- Product Description: Immunotag™ Protocadherin-11 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Protocadherin-11 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,IF,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PCDH-X/Y. AA range:531-580 |
| Specificity | Protocadherin-11 Polyclonal Antibody detects endogenous levels of Protocadherin-11 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PCDH11X/PCDH11Y |
| Accession No. | Q9BZA8/Q9BZA7 |
| Alternate Names | PCDH11Y; PCDH11; PCDH22; PCDHY; Protocadherin-11 Y-linked; Protocadherin-11; Protocadherin on the Y chromosome; PCDH-Y; Protocadherin prostate cancer; Protocadherin-PC; Protocadherin-22; PCDH11X; KIAA1326; PCDH11; PCDHX; Protocadherin-11 X- |
| Description | protocadherin 11 Y-linked(PCDH11Y) Homo sapiens This gene belongs to the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing seven cadherin repeats, a transmembrane domain, and a cytoplasmic tail that differs from those of the classical cadherins. This gene is located on the Y chromosome in a block of X/Y homology and is very closely related to its paralog on the X chromosome. The protein is thought to play a role in cell-cell recognition during development of the central nervous system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013], |
| Protein Expression | Brain,Prostatic carcinoma, |
| Subcellular Localization | plasma membrane,integral component of membrane, |
| Protein Function | Additional isoforms seem to exist,disease:A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2.,function:Potential calcium-dependent cell-adhesion protein.,similarity:Contains 7 cadherin domains.,subunit:Interacts with CTNNB1.,tissue specificity:Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. Expressed in apoptosis-resistant cells., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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