ITT3867
ITT3867
- Catalog: ITT3867
- Gene/Protein: PRPF31
- Product Description: Immunotag™ PRPF31 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PRPF31 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PRP31. AA range:331-380 |
| Specificity | PRPF31 Polyclonal Antibody detects endogenous levels of PRPF31 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PRPF31 |
| Accession No. | Q8WWY3 Q8CCF0 |
| Alternate Names | PRPF31; PRP31; U4/U6 small nuclear ribonucleoprotein Prp31; Pre-mRNA-processing factor 31; Serologically defined breast cancer antigen NY-BR-99; U4/U6 snRNP 61 kDa protein; Protein 61K; hPrp31 |
| Description | pre-mRNA processing factor 31(PRPF31) Homo sapiens This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009], |
| Cell Pathway/ Category | Spliceosome, |
| Protein Expression | Brain,Kidney,Mammary gland,Testis, |
| Subcellular Localization | nucleus,nucleoplasm,U2-type spliceosomal complex,U4 snRNP,U4atac snRNP,Cajal body,nuclear speck,viral nucleocapsid,U4/U6 x U5 tri-snRNP complex,precatalytic spliceosome,MLL1 complex, |
| Protein Function | disease:Defects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11) [MIM:600138]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP11 inheritance is autosomal dominant.,function:Involved in pre-mRNA splicing. Required for U4/U6.U5 tri-snRNP formation.,similarity:Contains 1 Nop domain.,subcellular location:Predominantly found in speckles and in Cajal bodies.,subunit:Part of a tri-snRNP complex. Interacts with C20orf14/U5 snRNP-associated 102 kDa protein.,tissue specificity:Ubiquitously expressed., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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