ITT3877
ITT3877
- Catalog: ITT3877
- Gene/Protein: PSCA
- Product Description: Immunotag™ PSCA Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PSCA |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Prostate Stem Cell Antigen. AA range:41-90 |
| Specificity | PSCA Polyclonal Antibody detects endogenous levels of PSCA protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PSCA |
| Accession No. | O43653 P57096 |
| Alternate Names | PSCA; Prostate stem cell antigen |
| Description | prostate stem cell antigen(PSCA) Homo sapiens This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010], |
| Protein Expression | Prostatic carcinoma,Skin,Urothelium, |
| Subcellular Localization | plasma membrane,anchored component of membrane,extracellular exosome, |
| Protein Function | function:May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.,induction:Down-regulated in gastric cancer cells.,polymorphism:Genetic variations in PSCA may influence susceptibility to diffuse-type gastric cancer.,similarity:Contains 1 UPAR/Ly6 domain.,tissue specificity:Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level)., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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