ITT3878
ITT3878
- Catalog: ITT3878
- Gene/Protein: DLG2
- Product Description: Immunotag™ PSD-93 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PSD-93 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DLG2. AA range:601-650 |
| Specificity | PSD-93 Polyclonal Antibody detects endogenous levels of PSD-93 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | DLG2 |
| Accession No. | Q15700 Q91XM9 |
| Alternate Names | DLG2; Disks large homolog 2; Channel-associated protein of synapse-110; Chapsyn-110; Postsynaptic density protein PSD-93 |
| Description | discs large MAGUK scaffold protein 2(DLG2) Homo sapiens This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008], |
| Protein Expression | Brain,Brain cortex,Caudate nucleus,Cerebellum,Retina, |
| Subcellular Localization | plasma membrane,voltage-gated potassium channel complex,ionotropic glutamate receptor complex,postsynaptic density,membrane,basolateral plasma membrane,cell junction,juxtaparanode region of axon,postsynaptic membrane, |
| Protein Function | domain:Isoform 2 has an L27 domain close to N-terminus.,function:Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses.,PTM:Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.,similarity:Belongs to the MAGUK family.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 3 PDZ (DHR) domains.,subcellular location:Concentrated in soma and postsynaptic density of a subset of neurons.,subunit:Interacts with NOS1/nNOS through second PDZ domain (By similarity). Interacts with C-terminus of KCNJ2/Kir2.1 through one of its PDZ domains., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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