ITT3899
ITT3899
- Catalog: ITT3899
- Gene/Protein: PTPRN2
- Product Description: Immunotag™ PTP IA-2β Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PTP IA-2β |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from PTP IA-2β, at AA range: 180-260 |
| Specificity | PTP IA-2β Polyclonal Antibody detects endogenous levels of PTP IA-2β protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PTPRN2 |
| Accession No. | Q92932 P80560 Q63475 |
| Alternate Names | PTPRN2; KIAA0387; Receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; Islet cell autoantigen-related protein; IAR; ICAAR; Phogrin |
| Description | protein tyrosine phosphatase, receptor type N2(PTPRN2) Homo sapiens This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015], |
| Cell Pathway/ Category | Type I diabetes mellitus, |
| Protein Expression | Amygdala,Brain,Fetal brain,Pancreas, |
| Subcellular Localization | endoplasmic reticulum lumen,integral component of plasma membrane,integral component of membrane,cell junction,secretory granule membrane,synaptic vesicle membrane,terminal bouton,receptor complex, |
| Protein Function | catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,disease:Autoantigen in insulin-dependent diabetes mellitus (IDDM).,domain:The cytoplasmic domain appears to contain the autoantigenic epitopes.,function:Implicated in development of nervous system and pancreatic endocrine cells.,PTM:Appears to undergo multiple proteolytic cleavage at consecutive basic residues.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,tissue specificity:Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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