ITT4035
ITT4035
- Catalog: ITT4035
- Gene/Protein: REC8
- Product Description: Immunotag™ Rec8 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Rec8 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human REC8. AA range:154-203 |
| Specificity | Rec8 Polyclonal Antibody detects endogenous levels of Rec8 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | REC8 |
| Accession No. | O95072 Q8C5S7 |
| Alternate Names | REC8; REC8L1; Meiotic recombination protein REC8 homolog; Cohesin Rec8p |
| Description | REC8 meiotic recombination protein(REC8) Homo sapiens This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Oocyte meiosis, |
| Protein Expression | Brain,Lung,Teratocarcinoma, |
| Subcellular Localization | condensed nuclear chromosome kinetochore,nuclear cohesin complex,lateral element,male germ cell nucleus,nucleus,meiotic cohesin complex,nuclear meiotic cohesin complex, |
| Protein Function | function:Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.,PTM:Phosphorylated.,similarity:Belongs to the rad21 family.,subcellular location:In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II.,subunit:Interacts in both phosphorylated and unphosphorylated forms with SMC3, SYCP3 and SMC1B but not with SMC1A. Also interacts with RAD51.,tissue specificity:Expressed in testis and thymus., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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