ITT4073
ITT4073
- Catalog: ITT4073
- Gene/Protein: RGS14
- Product Description: Immunotag™ RGS14 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | RGS14 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from RGS14, at AA range: 100-180 |
| Specificity | RGS14 Polyclonal Antibody detects endogenous levels of RGS14 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | RGS14 |
| Accession No. | O43566 P97492 O08773 |
| Alternate Names | RGS14; Regulator of G-protein signaling 14; RGS14 |
| Description | regulator of G-protein signaling 14(RGS14) Homo sapiens This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Caudate nucleus,Colon, |
| Subcellular Localization | spindle pole,intracellular,nucleus,cytoplasm,centrosome,spindle,microtubule,plasma membrane,postsynaptic density,nuclear body,PML body,cell junction,dendrite,dendritic spine,posts |
| Protein Function | function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.,similarity:Contains 1 GoLoco domain.,similarity:Contains 1 RGS domain.,similarity:Contains 2 RBD (Ras-binding) domains., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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