ITT4086
ITT4086
- Catalog: ITT4086
- Gene/Protein: RHO
- Product Description: Immunotag™ Rhodopsin Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | RHO Dopsin |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the Internal region of human Rhodopsin |
| Specificity | Rhodopsin Polyclonal Antibody detects endogenous levels of Rhodopsin protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | RHO |
| Accession No. | P08100 P15409 P51489 |
| Alternate Names | RHO; OPN2; Rhodopsin; Opsin-2 |
| Description | rhodopsin(RHO) Homo sapiens Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Regulation of Microtubule Dynamics, Regulation of Actin Dynamics, SAPK_JNK, B_Cell_Antigen |
| Protein Expression | Retina, |
| Subcellular Localization | Golgi membrane,photoreceptor outer segment,photoreceptor inner segment,Golgi apparatus,plasma membrane,integral component of plasma membrane,cell-cell junction,integral component of membrane,Golgi-associated vesicle membrane,photoreceptor outer segment membrane, |
| Protein Function | disease:Defects in RHO are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000].,disease:Defects in RHO are the cause of congenital stationary night blindness autosomal dominant type 1 (CSNBAD1) [MIM:610445]; also known as rhodopsin-related congenital stationary night blindness. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision.,disease:Defects in RHO are the cause of retinitis pigmentosa type 4 (RP4) [MIM:180380]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP4 inheritance is autosomal dominant.,function:Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.,online information:Retina International's Scientific Newsletter,online information:Rhodopsin entry,online information:Rhodopsin mutations page,PTM:Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.,similarity:Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.,tissue specificity:Rod shaped photoreceptor cells which mediates vision in dim light., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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