ITT4149
ITT4149
- Catalog: ITT4149
- Gene/Protein: RIT1
- Product Description: Immunotag™ Rit1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Rit1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RIT1. AA range:170-219 |
| Specificity | Rit1 Polyclonal Antibody detects endogenous levels of Rit1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | RIT1 |
| Accession No. | Q92963 P70426 |
| Alternate Names | RIT1; RIBB; RIT; ROC1; GTP-binding protein Rit1; Ras-like protein expressed in many tissues; Ras-like without CAAX protein 1 |
| Description | Ras like without CAAX 1(RIT1) Homo sapiens This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012], |
| Protein Expression | Esophagus,PCR rescued clones,Retina, |
| Subcellular Localization | intracellular,plasma membrane,membrane, |
| Protein Function | enzyme regulation:Alternate between an inactive form bound to GDP and an active form bound to GTP.,function:Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation.,miscellaneous:Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.,miscellaneous:Stimulation of the NGF and EGF receptor signaling pathways results in rapid and prolonged activation.,similarity:Belongs to the small GTPase superfamily. Ras family.,subunit:Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with RAF1. BARF and RAF1 association is dependent upon the GTP-bound state. Interacts with RGL3.,tissue specificity:Expressed in many tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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