ITT4232
ITT4232
- Catalog: ITT4232
- Gene/Protein: SEMA3A
- Product Description: Immunotag™ SEMA3A Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | SEMA3A |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the C-terminal region of human SEMA3A |
| Specificity | SEMA3A Polyclonal Antibody detects endogenous levels of SEMA3A protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SEMA3A |
| Accession No. | Q14563 O08665 Q63548 |
| Alternate Names | SEMA3A; SEMAD; Semaphorin-3A; Semaphorin III; Sema III |
| Description | semaphorin 3A(SEMA3A) Homo sapiens This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Axon guidance, |
| Protein Expression | Fetal brain, |
| Subcellular Localization | extracellular region,extracellular space,axon,dendrite, |
| Protein Function | domain:Strong binding to neuropilin is mediated by the carboxy third of the protein.,function:Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.,similarity:Belongs to the semaphorin family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 PSI domain.,similarity:Contains 1 Sema domain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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