ITT4240
ITT4240
- Catalog: ITT4240
- Gene/Protein: SENP6
- Product Description: Immunotag™ SENP6 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | SENP6 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SENP6. AA range:1042-1091 |
| Specificity | SENP6 Polyclonal Antibody detects endogenous levels of SENP6 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SENP6 |
| Accession No. | Q9GZR1 Q6P7W0 |
| Alternate Names | SENP6; KIAA0797; SSP1; SUSP1; FKSG6; Sentrin-specific protease 6; SUMO-1-specific protease 1; Sentrin/SUMO-specific protease SENP6 |
| Description | SUMO1/sentrin specific peptidase 6(SENP6) Homo sapiens Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for |
| Protein Expression | Brain,Epithelium,Testis,Tongue,Whole embryo, |
| Subcellular Localization | nucleoplasm,cytoplasm, |
| Protein Function | function:Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Does not seem to be involved in the processing of full-length SUMO proteins to their mature forms. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. May act preferentially on substrates containing 3 or more SUMO2 or SUMO3 moieties.,similarity:Belongs to the peptidase C48 family.,subunit:Interacts with RXRA.,tissue specificity:Highly expressed in reproductive organs, such as testis, ovary and prostate., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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