ITT4250
ITT4250
- Catalog: ITT4250
- Gene/Protein: SEPT6
- Product Description: Immunotag™ Septin 6 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | Septin 6 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SEPT6. AA range:223-272 |
| Specificity | Septin 6 Polyclonal Antibody detects endogenous levels of Septin 6 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SEPT6 |
| Accession No. | Q14141 Q9R1T4 |
| Alternate Names | SEPT6; KIAA0128; SEP2; Septin-6 |
| Description | septin 6(SEPT6) Homo sapiens This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008], |
| Protein Expression | Bone marrow,Muscle,Placenta,Platelet,Primary B-Cells,Testis, |
| Subcellular Localization | condensed chromosome kinetochore,spindle,septin ring,synaptic vesicle,midbody,septin complex,cleavage furrow,septin collar,axon terminus, |
| Protein Function | function:Involved in cytokinesis .,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the septin family.,subunit:Heterohexamer composed of two heterotrimers containing one copy each of SEPT2, SEPT6 and SEPT7. The asymmetrical heterotrimers associate head-to-head to form a hexameric unit that assembles into filaments. Interacts with SEPT12. Interaction with SEPT12 alters filament structure., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|