ITT4251
ITT4251
- Catalog: ITT4251
- Gene/Protein: SEPT7
- Product Description: Immunotag™ Septin 7 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | Septin 7 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000.IHC-p:1:50-300 ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Septin 7, at AA range: 320-400 |
| Specificity | Septin 7 Polyclonal Antibody detects endogenous levels of Septin 7 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SEPT7 |
| Accession No. | Q16181 O55131 Q9WVC0 |
| Alternate Names | SEPT7; CDC10; Septin-7; CDC10 protein homolog |
| Description | septin 7(SEPT7) Homo sapiens This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011], |
| Protein Expression | Brain,Epithelium,Fetal lung,Pooled,Testis,Uterus, |
| Subcellular Localization | condensed chromosome kinetochore,stress fiber,nucleus,nucleolus,cytoplasm,spindle,cytosol,plasma membrane,cell-cell adherens junction,axoneme,actin cytoskeleton,microtubule cytoskeleton,apical plasma membrane,midbody, |
| Protein Function | function:Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore.,similarity:Belongs to the septin family.,subcellular location:Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase.,subunit:Heterohexamer composed of two heterotrimers containing one copy each of SEPT2, SEPT6 and SEPT7. The asymmetrical heterotrimers associate head-to-head to form a hexameric unit that assembles into filaments. Interacts directly with CENPE and links CENPE to septin filaments composed of SEPT2, SEPT6 and SEPT7., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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