ITT4276
ITT4276
- Catalog: ITT4276
- Gene/Protein: SGOL2
- Product Description: Immunotag™ Sgo2 Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | Sgo2 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | IHC-p,ELISA |
Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | The antiserum was produced against synthesized peptide derived from human SGOL2. AA range:681-730 |
Specificity | Sgo2 Polyclonal Antibody detects endogenous levels of Sgo2 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | SGOL2 |
Accession No. | Q562F6 Q7TSY8 |
Alternate Names | SGOL2; Shugoshin-like 2; Shugoshin-2; Sgo2; Tripin |
Description | function:During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis (By similarity). May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the shugoshin family.,subcellular location:In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase.,subunit:Directly interacts with PPP2CA., |
Protein Expression | Epithelium,Lymph,Testis,Uterus, |
Subcellular Localization | chromosome, centromeric region,condensed chromosome kinetochore,nucleoplasm,cytosol,mitotic cohesin complex, |
Protein Function | function:During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis (By similarity). May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the shugoshin family.,subcellular location:In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase.,subunit:Directly interacts with PPP2CA., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |