ITT4342
ITT4342
- Catalog: ITT4342
- Gene/Protein: SMG7
- Product Description: Immunotag™ SMG7 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | SMG7 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SMG7. AA range:521-570 |
| Specificity | SMG7 Polyclonal Antibody detects endogenous levels of SMG7 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SMG7 |
| Accession No. | Q92540 Q5RJH6 |
| Alternate Names | SMG7; C1orf16; EST1C; KIAA0250; Protein SMG7; EST1-like protein C; SMG-7 homolog; hSMG-7 |
| Description | SMG7, nonsense mediated mRNA decay factor(SMG7) Homo sapiens This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011], |
| Protein Expression | Bone marrow,Brain,Epithelium,Testis, |
| Subcellular Localization | nucleus,telomerase holoenzyme complex,cytoplasm,cytosol,intermediate filament cytoskeleton, |
| Protein Function | function:Plays a role in nonsense-mediated mRNA decay. Recruits RENT1 to cytoplasmic mRNA decay bodies.,similarity:Contains 2 TPR repeats.,subcellular location:Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.,subunit:Part of a complex that contains SMG5, SMG7, PP2AC, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated RENT1., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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