ITT4348
ITT4348
- Catalog: ITT4348
- Gene/Protein: SMUG1
- Product Description: Immunotag™ SMUG1 Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | SMUG1 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC-p,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat,Monkey |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from SMUG1, at AA range: 60-140 |
Specificity | SMUG1 Polyclonal Antibody detects endogenous levels of SMUG1 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | SMUG1 |
Accession No. | Q53HV7 Q6P5C5 Q811Q1 |
Alternate Names | SMUG1; Single-strand selective monofunctional uracil DNA glycosylase |
Description | single-strand-selective monofunctional uracil-DNA glycosylase 1(SMUG1) Homo sapiens This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011], |
Cell Pathway/ Category | Base excision repair, |
Protein Expression | Adipose tissue,Brain,Liver,Muscle,Ovary,Ute |
Subcellular Localization | nucleoplasm,nucleolus, |
Protein Function | function:Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |