ITT4356
ITT4356
- Catalog: ITT4356
- Gene/Protein: SKIL
- Product Description: Immunotag™ SnoN Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | SnoN |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SKIL. AA range:616-665 |
| Specificity | SnoN Polyclonal Antibody detects endogenous levels of SnoN protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SKIL |
| Accession No. | P12757 Q60665 |
| Alternate Names | SKIL; SNO; Ski-like protein; Ski-related oncogene; Ski-related protein |
| Description | SKI like proto-oncogene(SKIL) Homo sapiens The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011], |
| Protein Expression | Kidney,Myoblast,Placenta,Umbilical vein endothelial cell, |
| Subcellular Localization | acrosomal vesicle,nucleus,nucleoplasm,transcription factor complex,cytoplasm,PML body,transcriptional repressor complex,protein complex, |
| Protein Function | function:May have regulatory role in cell division or differentiation in response to extracellular signals.,similarity:Belongs to the SKI family.,subunit:Interacts with SMAD2, SMAD3 and RNF111.,tissue specificity:SNON and SNOA isoforms are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Expression of isoform SNOI is restricted to skeletal muscle., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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