ITT4358
ITT4358
- Catalog: ITT4358
- Gene/Protein: SNX1
- Product Description: Immunotag™ SNX1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | SNX1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the Internal region of human SNX1 |
| Specificity | SNX1 Polyclonal Antibody detects endogenous levels of SNX1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SNX1 |
| Accession No. | Q13596 Q9WV80 Q99N27 |
| Alternate Names | SNX1; Sorting nexin-1 |
| Description | sorting nexin 1(SNX1) Homo sapiens This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Coronary artery,Liver,Muscle,Testis, |
| Subcellular Localization | cytoplasm,Golgi apparatus,cytosol,cell-cell adherens junction,endosome membrane,membrane,extrinsic component of membrane,lamellipodium,retromer complex,retromer, tubulation complex,early endosome membrane,vesicle,intracellula |
| Protein Function | function:May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with PtdIns(3,4,5)P3 and, with weaker affinity, with PtdIns(3,5)P2.,similarity:Belongs to the sorting nexin family.,similarity:Contains 1 PX (phox homology) domain.,subunit:Self-assembles into a complex of approximately 300 kDa (By similarity). Interacts with HGS (By similarity). Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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