ITT4404
ITT4404
- Catalog: ITT4404
- Gene/Protein: HTR4
- Product Description: Immunotag™ SR-4 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | SR-4 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from SR-4, at AA range: 110-190 |
| Specificity | SR-4 Polyclonal Antibody detects endogenous levels of SR-4 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | HTR4 |
| Accession No. | Q13639 P97288 Q62758 |
| Alternate Names | HTR4; 5-hydroxytryptamine receptor 4; 5-HT-4; 5-HT4; Serotonin receptor 4 |
| Description | 5-hydroxytryptamine receptor 4(HTR4) Homo sapiens This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010], |
| Cell Pathway/ Category | Calcium,Neuroactive ligand-receptor interaction, |
| Protein Expression | Brain,G-protein coupled receptors,Gut,Heart,Hippocampus,Small intestine, |
| Subcellular Localization | cytoplasm,endosome,plasma membrane,integral component of plasma membrane,membrane, |
| Protein Function | Additional isoforms seem to exist,function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.,subunit:Isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interacts with INADL, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including SLC9A3R1 and EZR.,tissue specificity:Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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