ITT4487
ITT4487
- Catalog: ITT4487
- Gene/Protein: SYT11
- Product Description: Immunotag™ Synaptotagmin XI Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | Synaptotagmin XI |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Synaptotagmin XI, at AA range: 150-230 |
| Specificity | Synaptotagmin XI Polyclonal Antibody detects endogenous levels of Synaptotagmin XI protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | SYT11 |
| Accession No. | Q9BT88 Q9R0N3 O08835 |
| Alternate Names | SYT11; KIAA0080; Synaptotagmin-11; Synaptotagmin XI; SytXI |
| Description | synaptotagmin 11(SYT11) Homo sapiens This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010], |
| Protein Expression | Amygdala,Bone marrow,Brain,Lymph, |
| Subcellular Localization | phagocytic cup,lysosome,plasma membrane,integral component of plasma membrane,synaptic vesicle,postsynaptic density,cell junction,axon,synaptic vesicle membrane,early phagosome,neuron projection,dendritic spine,cell body, |
| Protein Function | cofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.,function:May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.,PTM:Ubiquitinated and targeted to the proteasome complex for degradation.,similarity:Belongs to the synaptotagmin family.,similarity:Contains 2 C2 domains.,subcellular location:In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients.,subunit:Homodimer. Can also form heterodimers (By similarity). Interacts with PARK2., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|