ITT4510
ITT4510
- Catalog: ITT4510
- Gene/Protein: TAS2R43
- Product Description: Immunotag™ T2R43 Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | T2R43 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | The antiserum was produced against synthesized peptide derived from human TAS2R43. AA range:124-173 |
Specificity | T2R43 Polyclonal Antibody detects endogenous levels of T2R43 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | TAS2R43 |
Accession No. | P59537 |
Alternate Names | TAS2R43; Taste receptor type 2 member 43; T2R43; Taste receptor type 2 member 52; T2R52 |
Description | taste 2 receptor member 43(TAS2R43) Homo sapiens TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009], |
Cell Pathway/ Category | Taste transduction, |
Protein Expression | Brain, |
Subcellular Localization | plasma membrane,integral component of membrane,motile cilium,ciliary membrane, |
Protein Function | function:Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Activated by the sulfonyl amide sweeteners saccharin and acesulfame K.,miscellaneous:Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |