ITT4533
ITT4533
- Catalog: ITT4533
- Gene/Protein: CPB2
- Product Description: Immunotag™ TAFI Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TAFI |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CPB2. AA range:321-370 |
| Specificity | TAFI Polyclonal Antibody detects endogenous levels of TAFI protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CPB2 |
| Accession No. | Q96IY4 Q9JHH6 |
| Alternate Names | CPB2; Carboxypeptidase B2; Carboxypeptidase U; CPU; Plasma carboxypeptidase B; pCPB; Thrombin-activable fibrinolysis inhibitor; TAFI |
| Description | carboxypeptidase B2(CPB2) Homo sapiens Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013], |
| Cell Pathway/ Category | Complement and coagulation cascades, |
| Protein Expression | Liver,Plasma,Skeletal muscle, |
| Subcellular Localization | extracellular space,cell,extracellular exosome, |
| Protein Function | catalytic activity:Release of C-terminal Arg and Lys from a polypeptide.,cofactor:Binds 1 zinc ion per subunit.,function:Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities.,similarity:Belongs to the peptidase M14 family.,tissue specificity:Plasma; synthesized in the liver., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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