ITT4584
ITT4584
- Catalog: ITT4584
- Gene/Protein: CCT5
- Product Description: Immunotag™ TCP-1 ε Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | TCP-1 ε |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from TCP-1 ε, at AA range: 210-290 |
Specificity | TCP-1 ε Polyclonal Antibody detects endogenous levels of TCP-1 ε protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | CCT5 |
Accession No. | P48643 P80316 Q68FQ0 |
Alternate Names | CCT5; CCTE; KIAA0098; T-complex protein 1 subunit epsilon; TCP-1-epsilon; CCT-epsilon |
Description | chaperonin containing TCP1 subunit 5(CCT5) Homo sapiens The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015], |
Protein Expression | Bone marrow,Brain,Cajal-Retzius cell,Embryonic kidney,Fetal brain c |
Subcellular Localization | zona pellucida receptor complex,nucleolus,cytoplasm,centrosome,cytosol,chaperonin-containing T-complex,microtubule,myelin sheath,cell body,extracellular exosome, |
Protein Function | disease:Defects in CCT5 are the cause of autosomal recessive sensory neuropathy with spastic paraplegia [MIM:256840]. The disease is characterized by spastic paraplegia and progressive distal sensory neuropathy leading to mutilating ulcerations of the upper and lower limbs.,function:Molecular chaperone; assist the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.,similarity:Belongs to the TCP-1 chaperonin family.,subunit:Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |