ITT4617
ITT4617
- Catalog: ITT4617
- Gene/Protein: GTF2H2
- Product Description: Immunotag™ TFIIH p44 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | TFIIH p44 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from TFIIH p44, at AA range: 1-80 |
| Specificity | TFIIH p44 Polyclonal Antibody detects endogenous levels of TFIIH p44 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GTF2H2 |
| Accession No. | Q13888 Q9JIB4 A0JN27 |
| Alternate Names | GTF2H2; BTF2P44; General transcription factor IIH subunit 2; Basic transcription factor 2 44 kDa subunit; BTF2 p44; General transcription factor IIH polypeptide 2; TFIIH basal transcription factor complex p44 subunit |
| Description | general transcription factor IIH subunit 2(GTF2H2) Homo sapiens This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of t |
| Cell Pathway/ Category | Basal transcription factors,Nucleotide excision repair, |
| Protein Expression | Brain,Liver,Pituitary tumor,Pre-B cell,Skin,Stomach,Testis, |
| Subcellular Localization | core TFIIH complex,nucleoplasm,transcription factor TFIID complex,holo TFIIH complex, |
| Protein Function | A number of isoforms may be produced. The isoforms may be also produced by incomplete gene duplication,function:Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.,function:Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.,similarity:Belongs to the GTF2H2 family.,similarity:Contains 1 VWFA domain.,subunit:One of the six subunits forming the core-TFIIH basal transcription factor. Interacts with XPB, XPD, GTF2H1 and GTF2H3.,tissue specificity:Widely expressed, with higher expression in skeletal muscle., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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