ITT4625
ITT4625
- Catalog: ITT4625
- Gene/Protein: TGM2
- Product Description: Immunotag™ TGase2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TGase2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Transglutaminase 2. AA range:1-50 |
| Specificity | TGase2 Polyclonal Antibody detects endogenous levels of TGase2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | TGM2 |
| Accession No. | P21980 P21981 |
| Alternate Names | TGM2; Protein-glutamine gamma-glutamyltransferase 2; Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2 |
| Description | transglutaminase 2(TGM2) Homo sapiens Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Huntington's disease, |
| Protein Expression | Brain,Colon adenocarcinoma,Endothelial cell,Kidney,Liver,Lymph node,Ovarian carcino |
| Subcellular Localization | intracellular,mitochondrion,endoplasmic reticulum,cytosol,plasma membrane,focal adhesion,extracellular matrix,intrinsic component of plasma membrane,extracellular exosome, |
| Protein Function | catalytic activity:Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).,cofactor:Binds 1 calcium ion per subunit.,disease:Defects in TGM2 are involved in early-onset diabetes type 2.,function:Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.,induction:By retinoic acid.,online information:Tissue transglutaminase entry,similarity:Belongs to the transglutaminase superfamily. Transglutaminase family.,subunit:Monomer., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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