ITT4634
ITT4634
- Catalog: ITT4634
- Gene/Protein: TGFB3
- Product Description: Immunotag™ TGFβ3 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TGFβ3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat,Monkey |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from TGFβ3, at AA range: 230-310 |
| Specificity | TGFβ3 Polyclonal Antibody detects endogenous levels of TGFβ3 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | TGFB3 |
| Accession No. | P10600 P17125 Q07258 |
| Alternate Names | TGFB3; Transforming growth factor beta-3; TGF-beta-3 |
| Description | transforming growth factor beta 3(TGFB3) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,Cytokine-cytokine receptor interaction,Cell_Cycle_G1S,Cell_Cycle_G2M_DNA,TGF-beta,Intestinal immune network for IgA production,Pathways in cancer,Colorectal cancer,Renal cell carcinoma,Pancreatic cancer,Chronic myeloid leukemia,Hypertrophic cardiomyopathy (HCM),Dilated cardiomyopathy, |
| Protein Expression | Amygdala,Esophageal,Placenta,Prostate, |
| Subcellular Localization | extracellular region,extracellular space,nucleus,plasma membrane,cell surface,secretory granule,T-tubule,extracellular matrix,platelet alpha granule lumen,neuronal cell body, |
| Protein Function | disease:Defects in TGFB3 are a cause of familial arrhythmogenic right ventricular dysplasia 1 (ARVD1) [MIM:107970]; also known as arrhythmogenic right ventricular cardiomyopathy 1 (ARVC1). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.,function:Involved in embryogenesis and cell differentiation.,online information:TGF beta-3 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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