ITT4645
ITT4645
- Catalog: ITT4645
- Gene/Protein: F2R
- Product Description: Immunotag™ Thrombin R Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Thrombin R |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Thrombin Receptor. AA range:10-59 |
| Specificity | Thrombin R Polyclonal Antibody detects endogenous levels of Thrombin R protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | F2R |
| Accession No. | P25116 P30558 |
| Alternate Names | F2R; CF2R; PAR1; TR; Proteinase-activated receptor 1; PAR-1; Coagulation factor II receptor; Thrombin receptor |
| Description | coagulation factor II thrombin receptor(F2R) Homo sapiens Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015], |
| Cell Pathway/ Category | Akt_PKB,Calcium,Neuroactive ligand-receptor interaction,Endocytosis,Complement and coagulation cascades,Regulates Actin and Cytoskeleton, |
| Protein Expression | Eye, |
| Subcellular Localization | extracellular region,cell,early endosome,late endosome,Golgi apparatus,plasma membrane,integral component of plasma membrane,caveola,cell surface,integral component of membrane,platelet dense tubular network,neur |
| Protein Function | function:High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,PTM:Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Platelets and vascular endothelial cells., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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