ITT4667
ITT4667
- Catalog: ITT4667
- Gene/Protein: TIRAP
- Product Description: Immunotag™ TIRAP Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TIRAP |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,WB,ELISA |
| Recommended Dilution | WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TIRAP. AA range:52-101 |
| Specificity | TIRAP Polyclonal Antibody detects endogenous levels of TIRAP protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | TIRAP |
| Accession No. | P58753 Q99JY1 |
| Alternate Names | TIRAP; MAL; Toll/interleukin-1 receptor domain-containing adapter protein; TIR domain-containing adapter protein; Adaptor protein Wyatt; MyD88 adapter-like protein |
| Description | TIR domain containing adaptor protein(TIRAP) Homo sapiens The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Toll_Like, |
| Protein Expression | Blood,Brain,Dendritic cell,Trachea, |
| Subcellular Localization | nucleoplasm,cytoplasm,cytosol,plasma membrane,endocytic vesicle,ruffle membrane,intercellular bridge, |
| Protein Function | function:Adapter involved in the TLR4 signaling pathway in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, resulting in cytokine secretion and the inflammatory response.,polymorphism:Genetic variation in TIRAP can influence susceptibility or resistance to invasive pneumococcal disease, bacteremia, malaria and tuberculosi.,similarity:Contains 1 TIR domain.,subunit:Homodimer. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their respective TIR domains. Binds to PKR and TBK1. Does not interact with IRAK1, nor TLR9.,tissue specificity:Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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