ITT4698
ITT4698
- Catalog: ITT4698
- Gene/Protein: TOP3B
- Product Description: Immunotag™ Topo IIIβ-1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Topo IIIβ-1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TOP3B. AA range:51-100 |
| Specificity | Topo IIIβ-1 Polyclonal Antibody detects endogenous levels of Topo IIIβ-1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | TOP3B |
| Accession No. | O95985 Q9Z321 |
| Alternate Names | TOP3B; TOP3B1; DNA topoisomerase 3-beta-1; DNA topoisomerase III beta-1 |
| Description | topoisomerase (DNA) III beta(TOP3B) Homo sapiens This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013], |
| Cell Pathway/ Category | Homologous recombination, |
| Protein Expression | Skin, |
| Subcellular Localization | condensed chromosome,nucleus,cytosol, |
| Protein Function | catalytic activity:ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.,function:Possesses negatively supercoiled DNA relaxing activity.,similarity:Belongs to the prokaryotic type I/III topoisomerase family.,tissue specificity:Isoform 1 is found in testis, heart and skeletal muscle. A 4 kb transcript which probably represents isoform 2 is found in thymus, kidney and pancreas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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