ITT4872
ITT4872
- Catalog: ITT4872
- Gene/Protein: FIGF
- Product Description: Immunotag™ VEGF-D Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | VEGF-D |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat,Monkey |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from the Internal region of human VEGF-D |
| Specificity | VEGF-D Polyclonal Antibody detects endogenous levels of VEGF-D protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | FIGF |
| Accession No. | O43915 P97946 O35251 |
| Alternate Names | FIGF; VEGFD; Vascular endothelial growth factor D; VEGF-D; c-Fos-induced growth factor; FIGF |
| Description | vascular endothelial growth factor D(VEGFD) Homo sapiens The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011], |
| Cell Pathway/ Category | Cytokine-cytokine receptor interaction,mTOR,Focal adhesion,Pathways in cancer,Renal cell carcinoma,Pancreatic cancer,Bladder cancer, |
| Protein Expression | Human lung,Lung, |
| Subcellular Localization | extracellular region,extracellular space,membrane,platelet alpha granule lumen, |
| Protein Function | function:Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (Flk1) and VEGFR-3 (Flt4) receptors.,PTM:Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.,similarity:Belongs to the PDGF/VEGF growth factor family.,subunit:Homodimer; non-covalent and antiparallel.,tissue specificity:Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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